Human [T.sub.17] lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Article Abstract:
The influence of expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions are presented. The T-helper type 1 and type 17 lymphocytes are shown to transmigrate efficiently across BBB-ECs and kill human neurons promoting central nervous system inflammation through [CD4.sup.} lymphocyte recruitment.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Building up the blood-brain barrier
Article Abstract:
The diseases like strokes, brain tumors, traumatic injury or multiple sclerosis, which lead to blocking of the central nervous system, are accompanied by dysfunction of the (BBB). The Src-suppressed C kinase substrate SSeCKS, the main factor that triggers signaling of the cascades that keep the blood-brain-barrier(BBB) function is identified.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier
Article Abstract:
The effects of blood-brain-barrier(BBB) and src-suppressed C-kinase (SSeCKS) on the that lead to brain disorders like Alzheimer and Ischemic are illustrated. The Modulation of both brain angiogenesis and tight junction formation is regulated by SSeCKS by differentiation of BBB.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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